Preservation of early discharge of muscle afferents in acrylamide neuropathy.

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Acrylamide neuropathy

By Michael T Pulley MD PhD (Dr. Pulley of the University of Florida, Jacksonville has received consulting fees from Walgreens Home Infusion.) Alan R Berger MD (Dr. Berger of the University of Florida, Jacksonville and the Neuroscience Institute at Shands Jacksonville has no relevant financial relationships to disclose.) Originally released December 3, 1999; last updated April 12, 2017; expires ...

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The effect of pinna reflex and dynamic stretch on spike discharge of single ?-axons and spindle afferents in caudal muscle spindles in rat

The ?-axons supplying muscle spindle (MS) induce a particular pattern of activity in spindle Ia and II afferents on contraction. From a dynamic viewpoint, the Ia shows increasing spike rates, but II-afferents do not show any activity. For evaluation of nerve fiber activity, spike amplitude (SA) is suggested to measure it as well as its benefit of diagnosing clinical symptoms. This paper aims to...

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The effect of pinna reflex and dynamic stretch on spike discharge of single ?-axons and spindle afferents in caudal muscle spindles in rat

The ?-axons supplying muscle spindle (MS) induce a particular pattern of activity in spindle Ia and II afferents on contraction. From a dynamic viewpoint, the Ia shows increasing spike rates, but II-afferents do not show any activity. For evaluation of nerve fiber activity, spike amplitude (SA) is suggested to measure it as well as its benefit of diagnosing clinical symptoms. This paper aims to...

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Megaoesophagus due to acrylamide neuropathy.

Greyhound dogs exposed to oral acrylamide for a period of eight weeks developed a sensorimotor peripheral neuropathy that had many features in common with acrylamide neuropathy seen in other species. Most of the animals also developed the clinical and radiological features of megaoesophagus. The association of neuropathy and megaoesophagus suggests that an axonopathy of the vagus may be an aeti...

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Altered Sensory Ganglia in Acrylamide Neuropathy

To learn more about the nerve cell body in neurotoxin-induced degeneration of axons, Sprague-Dawley rats were intoxicated with 50 mg/kg/day of the prototype neurotoxin acrylamide monomer. The lumbar dorsal root ganglia were studied in those rats with progressive disease (controls were not intoxicated). Qualitative changes in cytological organization included nuclear eccentricity. reduction in t...

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ژورنال

عنوان ژورنال: The Journal of Physiology

سال: 1975

ISSN: 0022-3751

DOI: 10.1113/jphysiol.1975.sp010890